Aging is caused by the main pathogenic factor initiating this disease – oxygen deficiency in organs and tissues. Hypoxia accelerates the degeneration of the weak link – the sensitive nerve endings of the autonomic nervous system. The sequence of events connected by a network of cause-and-effect relationships and representing the pathogenesis of aging disease is considered. The second etiological factor that determines the pathogenesis of aging disease is local hyperoxia of stem cell niches, which leads to accelerated differentiation of stem cells and, as a result, to age-related depletion of their pools. Within the framework of the Concept, the explanation of known significant facts that characterize this disease, but which have not received a clear explanation within the framework of other hypotheses, is considered. Acquisition of disease status by aging makes it possible not only to actively slow down aging, but also to reverse it.

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